Policy entrepreneurs are energetic actors who work with others in and around policymaking venues to promote significant policy change. After several decades of study, we know a lot about what policy entrepreneurs do, and how to assess their effectiveness in given policymaking contexts. Here, we review common practices of policy entrepreneurs, emphasising their problem framing activities and their role in catalysing large-scale behavioural change related to climate change. We then review what policy entrepreneurs operating in various locations and at different levels of government have begun doing to tackle the climate change challenge. Like others, we contend that policy entrepreneurs will play a vital role in future efforts to address climate change. We conclude by discussing opportunities for new research on policy entrepreneurship, policymaking processes and the diffusion of policy innovations relating to climate change.